課程名稱 |
基因體研究特論 Special Topics in Genomic Studies |
開課學期 |
106-1 |
授課對象 |
學程 生物統計學程 |
授課教師 |
郭柏秀 |
課號 |
EPM7181 |
課程識別碼 |
849 M0750 |
班次 |
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學分 |
2.0 |
全/半年 |
半年 |
必/選修 |
選修 |
上課時間 |
星期三3,4(10:20~12:10) |
上課地點 |
公衛209 |
備註 |
與張弘潔、林菀俞、盧子彬合授 限碩士班以上 總人數上限:15人 |
Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1061EPM7181_ |
課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
課程大綱
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為確保您我的權利,請尊重智慧財產權及不得非法影印
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課程概述 |
The major goal of this course is to learn the concepts, new methods and findings of a wide-range of topics in genomic studies through reading and discussion of original articles. Selected articles of each topic have a major theme and involved various issues commonly encountered in genomic studies. Course will begin with an introductory lecture to point out important issues. Students are expected to read assigned articles in advance and discuss the designated questions during class. We’ll cover topics related to a) Study design, data analysis and integration; b) Assessment of human genome variation and regulation; c) Using genomic information in medicine and public health; and d) Ethical issues in using genomic data. |
課程目標 |
1. To learn the concepts, new methods and findings of a wide-range of topics in genomic studies.
2. To learn how to read critically original articles in genomic studies.
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課程要求 |
[具備基礎遺傳學知識,或修習過遺傳流行病學原理、其他授課教師認可之遺傳相關課程]
Class participation: including presentation and discussion.
Assignments: written discussion about the designated questions listed in each session.
Final report: choose a topic and describe concisely the design, main findings, unsolved problems, and future directions of studies in the field.
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預期每週課後學習時數 |
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Office Hours |
另約時間 |
指定閱讀 |
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參考書目 |
Human Genome Epidemiology, 2nd Edition
Building the evidence for using genetic information to improve health and
prevent disease.
Edited by
Muin Khoury, Sara Bedrosian, Marta Gwinn, Julian Higgins, John Ioannidis,
and Julian Little |
評量方式 (僅供參考) |
No. |
項目 |
百分比 |
說明 |
1. |
Class participation |
50% |
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2. |
Class assignments |
20% |
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3. |
Final report |
30% |
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週次 |
日期 |
單元主題 |
第1週 |
09/13 |
Course introduction and introduction of genomic epidemiology |
第2週 |
09/20 |
Genome-wide association studies |
第3週 |
09/27 |
Risk prediction |
第4週 |
10/04 |
Mid-Autumn Festival (holiday) |
第5週 |
10/11 |
Pharmacogenomics (調課10/03 or 10/05) |
第6週 |
10/18 |
Rare variants introduction (盧子彬) |
第7週 |
10/25 |
Common and rare variants in public health applications |
第8週 |
11/01 |
Rare variants analysis (林菀俞) |
第9週 |
11/08 |
Incorporating interactions |
第10週 |
11/15 |
Anniversary celebration of NTU (holiday) |
第11週 |
11/22 |
Epigenetics |
第12週 |
11/29 |
Gene expression and -omic data |
第13週 |
12/06 |
Pathway-based analysis |
第14週 |
12/13 |
Ethical issues in using genomic data (張弘潔) |
第15週 |
12/20 |
Metagenomics |
第16週 |
12/27 |
Final presentation (盧子彬) |
第17週 |
01/03 |
Final presentation (盧子彬) |